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Some people notice dryness mainly during dose increases

Additionally, it must be noted that an individual biomarker, for example, sKlotho, inherently has some limitations for accurate diagnosis and monitoring progression in CKD without the combination of a set of other biomarkers because a single indicator lacks sufficient performance and efficiency to reflect the complexity of the mechanisms underlying CKD pathogenesis and development

However, it's important to note that these effects are not fully understood or widely accepted, and further research is needed to confirm any sexual enhancement benefits